Mark Grigorievich Krein (Russian: Марк Григо́рьевич Крейн; Ukrainian: Марко́ Григо́рович Крейн; 3 April 1907 – 17 October 1989) was a Soviet mathematician, one of the major figures of the Soviet school of functional analysis. He is known for works in operator theory (in close connection with concrete problems coming from mathematical physics), the problem of moments, classical analysis and representation theory.